Sirtex Medical Announces New Immuno-Oncology Combination Study Launched

Sirtex Medical Limited (ASX:SRX) today announces the launch of a new Investigator Initiated Trial (IIT) in non-resectable advanced hepatocellular carcinoma (HCC), the most common type of primary liver cancer. The study, known as NASIR-HCC, is a multi-centre, open label, single-arm study of the safety and anti-tumour efficacy of Opdivo® (nivolumab, Bristol-Myers Squibb Company) after SIRSpheres microspheres for the treatment of patients with HCC that are candidates for loco-regional therapies. The primary endpoint is safety. Key secondary endpoints include Overall Survival (OS), Objective Response Rate (ORR), Disease Control Rate (DCR), Time to Progression (TTP) and Progression-Free Survival (PFS). The study is expected to recruit 40 patients.

The principal investigator of the study is Professor Bruno Sangro, Director of the Liver Unit at Clinica Universidad de Navarra, Spain. Sirtex is a financial sponsor of the study.

The scientific hypothesis underpinning the rationale for the study combination is that by inducing tumour cell death, SIR-Spheres may have a synergistic effect with immune checkpoint inhibitors by priming the immune system via the radiation-induced release of tumour antigens prior to treatment with nivolumab, which additionally takes the handbrake off immune system recognition of cancer cells.

Mr Andrew McLean, Chief Executive Officer of Sirtex Medical said “The NASIR-HCC study forms part of our clinical strategy that seeks to add value to our core product through small, targeted IITs using our therapy in combination with drug-based treatments like checkpoint inhibitors, which are in clinical development for a range of different cancer types, including HCC. This is the second IIT looking at this unique combination, with a similar study ongoing in Singapore.”

The advice given by Kalkine Pty Ltd and provided on this website is general information only and it does not take into account your investment objectives, financial situation or needs. You should therefore consider whether the advice is appropriate to your investment objectives, financial situation and needs before acting upon it. You should seek advice from a financial adviser, stockbroker or other professional (including taxation and legal advice) as necessary before acting on any advice. Not all investments are appropriate for all people. and associated websites are published by Kalkine Pty Ltd ABN 34 154 808 312 (Australian Financial Services License Number 425376). The information on this website has been prepared from a wide variety of sources, which Kalkine Pty Ltd, to the best of its knowledge and belief, considers accurate. You should make your own enquiries about any investments and we strongly suggest you seek advice before acting upon any recommendation. Kalkine Pty Ltd has made every effort to ensure the reliability of information contained in its newsletters and websites. All information represents our views at the date of publication and may change without notice. To the extent permitted by law, Kalkine Pty Ltd excludes all liability for any loss or damage arising from the use of this website and any information published (including any indirect or consequential loss, any data loss or data corruption). If the law prohibits this exclusion, Kalkine Pty Ltd hereby limits its liability, to the extent permitted by law to the resupply of services. There may be a product disclosure statement or other offer document for the securities and financial products we write about in Kalkine Reports. You should obtain a copy of the product disclosure statement or offer document before making any decision about whether to acquire the security or product. The link to our Terms & Conditions has been provided please go through them and also have a read of the Financial Services Guide. On the date of publishing this report (mentioned on the website), employees and/or associates of Kalkine Pty Ltd do not hold positions in any of the stocks covered on the website. These stocks can change any time and readers of the reports should not consider these stocks as advice or recommendations.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s